Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
    Users Online: 430
Home Print this page Email this page Small font size Default font size Increase font size
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 5-8

The basic concept of the tumor stem cell model

Department of Pediatrics, Division of Hematology and Oncology, Developmental Biology and Stem Cell Program, Hospital for Sick Children, Toronto, Canada

Correspondence Address:
Bikul Das
Department of Pediatrics, Developmental Biology and Stem Cell Program, Hospital for Sick Children, Toronto
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0521.94977

Rights and Permissions

Both theoretical and experimental evidence support the concept of a tumor stem cell (TSC) model - a rare population of self-renewing stem cells among the heterogeneous mixture of tumor cells essential for solid tumor growth and progression. However, this growing evidence is not by itself convincing without an adequate molecular mechanism explaining how these TSCs maintain their stemness, since there is always a possibility that the so-called solid tumor TSCs may be a highly tumorigenic fraction of the heterogeneous mixture of tumor cells. The lack of knowledge of how TSCs maintain their state of stemness is therefore a major limitation that requires attention in order to improve our understanding on the stem cell model of tumor growth. An emerging and provocative concept in tumor biology is that a rare population of tumor stem cells exists among the heterogeneous population of cells within tumors. The TSC model suggests that proliferative potential and growth patterns of many human tumors may depend upon a small proportion of tumor stem cells that lead to repopulation following cytotoxic therapy. In this review, we will briefly discuss the basic concept of the TSC model and the emerging findings of the existence of the TSC fraction, even in established tumor cell lines.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded366    
    Comments [Add]    

Recommend this journal