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Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 47-49

Isoniazid and rifampicin induced fever in a patient with tuberculous pleural effusion

1 Department of Respiratory Medicine, Medical College, Kolkata, India
2 Department of Respiratory Medicine, Institute of Postgraduate Medical Education and Research, Kolkata, India
3 Department of Respiratory Medicine, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal, India

Correspondence Address:
Sibes Kumar Das
Souhardya Apartment, West Bankim Pally, P.O. Madhyamgram, Kolkata - 700 129, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0521.130209

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A 52-year-old male patient of right sided tuberculous pleural effusion developed fever with chill and rigor 12 days following therapy with antituberculous drugs. After careful clinical evaluation and investigations, it was proved to be a case of drug-induced fever. Isoniazid (H) and rifampicin (R) were found to be the offending drugs in re-challenge test. He was subsequently put on a modified regimen excluding these drugs and he made an uneventful recovery. We are reporting this case because of very rare occurrence of drug-induced fever with both R and H and presence of few atypical manifestations of drug fever in this case. Drug induced fever should be considered in a patient of tuberculosis developing fever during chemotherapy. Drug fever may sometimes be produced by more than one drug simultaneously.

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