| REVIEW ARTICLE |
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| Year : 2021 | Volume
: 10
| Issue : 3 | Page : 149-154 |
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The effect of Vitamin D in multiple sclerosis: An updated review
Amal Mohammad Alkhotani, Mawddah Hassan Faqeeh, Raghad Sameer Aldoobi, Ghofran Essam Sheikh, Rama Hassan Halabi, Wasan Khalid Alsharif
Department of Medicine, Umm AlQura University, College of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia
Correspondence Address:
Mawddah Hassan Faqeeh
College of Medicine, Umm Al-Qura University, Makkah 24372
Kingdom of Saudi Arabia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/sjhs.sjhs_70_21
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Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements.
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