Saudi Journal for Health Sciences

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 7  |  Issue : 1  |  Page : 28--32

Shelf life study of extemporaneously prepared omeprazole oral suspension


Hafiz Antar Makeen1, Shyam Sunder Pancholi2, Mohammad Sajid Ali2, Mohammad Intakhab Alam2, Mohammad Sarfaraz Alam2, Ali Mohammed Redaie3, Ahmad A Albarraq1, Mohammad Al-Bratty4, Yahya J Kadomi2, Mohammad Ali Qasim Attiya2, Salim Hussian Aribi2 
1 Department of Clinical Pharmacy, Pharmacy Practice Research Unit (PPRU), Jazan, Kingdom of Saudi Arabia
2 Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia
3 Department of Pharmacy, King Fahad Central Hospital, Jazan, Kingdom of Saudi Arabia
4 Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia

Correspondence Address:
Hafiz Antar Makeen
College of Pharmacy, Jazan University, P.O. Box 114, Jazan 45142
Kingdom of Saudi Arabia

Context: The commercially available oral solid dosage forms are used to prepare suitable liquid dosage forms extemporaneously by the pharmacists for pediatric, geriatric, and other patients with inability of swallowing tablets or capsules. These extemporaneous preparations are not subjected to tests for quality and stability like commercial products. The stability of extemporaneous preparations should be determined in hospital settings, but the practice is to rely on published information. Unavailability of stability data limits the availability of many medicines for special patients. The extemporaneously prepared omeprazole suspension is regularly used in hospital settings. Aim: This research was taken up to perform the stability study of extemporaneous omeprazole oral suspension frequently used in a referral hospital to determine the shelf life. Materials and Methods: Stability studies were performed by keeping the freshly constituted preparations in small containers at 2°C–8°C and 25°C ± 5°C; samples were withdrawn at 0, 7, 14, 21, and 28 days and assayed by spectrophotometric method at 301 nm. The percent degradation or stability was calculated for each preparation, and data were extrapolated to find out the shelf life. Results: It was found that the shelf life (t90%) of omeprazole oral suspension, prepared extemporaneously, is 32 days at room temperature (25°C ± 5°C) and 54 days in refrigerator (2°C–8°C). Conclusion: Study outcomes shall help the hospital pharmacist to improve pharmaceutical services by dispensing the extemporaneous preparations with the knowledge of their stability and storage condition.


How to cite this article:
Makeen HA, Pancholi SS, Ali MS, Alam MI, Alam MS, Redaie AM, Albarraq AA, Al-Bratty M, Kadomi YJ, Qasim Attiya MA, Aribi SH. Shelf life study of extemporaneously prepared omeprazole oral suspension.Saudi J Health Sci 2018;7:28-32


How to cite this URL:
Makeen HA, Pancholi SS, Ali MS, Alam MI, Alam MS, Redaie AM, Albarraq AA, Al-Bratty M, Kadomi YJ, Qasim Attiya MA, Aribi SH. Shelf life study of extemporaneously prepared omeprazole oral suspension. Saudi J Health Sci [serial online] 2018 [cited 2022 Aug 11 ];7:28-32
Available from: https://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2018;volume=7;issue=1;spage=28;epage=32;aulast=Makeen;type=0